News — Oak Brook, Illinois – Volume 28, number 5 of SLAS technologyincludes two review articles, six original research articles, and a short communication on test development with machine learning, new laboratory automation systems, and other areas of life sciences research.
- A rapid, high-throughput viral infectivity test using automated brightfield microscopy with machine learning The authors present an Automated Viral Infectivity Assay (AVIATM) that uses convolutional neural networks (CNN) and high-throughput bright-field microscopy to rapidly quantify the infection phenotypes of various viruses, providing a faster and faster alternative. more precise to traditional infectivity tests for the characterization and potential of viruses. identification.
- The Tecan SiLA2 SDK: an open source and royalty-free framework for developing SiLA2 servers and clients This research article presents Tecan’s open source framework, SiLA2 SDK, which simplifies the integration of laboratory devices with proprietary interfaces into automation platforms, demonstrating its applicability through case studies of integration of various devices using the SiLA2 standard.
- A sticky probe biosensor for homogeneous detection of transcription factor binding activity This paper studies the design and optimization of a sticky-end probe biosensor for the homogeneous detection of transcription factor-DNA binding activity, aiming to simplify the process of therapeutic screening and disease diagnosis.
- Screening Station, a new laboratory automation system for physiologically relevant cellular analyzes This report uses the Screening Station to automate the complex processes involved in cellular analyzes using cells derived from human induced pluripotent stem cells (iPSCs), enabling long-term culture, real-time imaging analyzes and immunofluorescence, with the potential to improve reproducibility. , save time and support remote experimentation.
- Development and validation of an automated test for anti-drug antibodies in rat serum The authors present the development of automated screening and confirmation ELISAs to detect rat antibodies against a therapeutic human monoclonal antibody (DH1042) for SARS-CoV-2, demonstrating their ability to assess the immunogenicity of such antibodies in preclinical testing and suggesting their potential applicability. to other organic products.
- Capillary electrophoresis methods to determine the critical IVT mRNA quality attributes of size and purity This article discusses the importance of quality control of in vitro transcribed (IVT) mRNAs, presenting methods for assessing IVT mRNA purity and poly(A) tail length using hair gel electrophoresis.
Access to the October 2023 issue of SLAS technology is available at https://slas-technology.org/issue/S2472-6303(23)X0006-5
SLAS technology reveals how scientists are adapting technological advances for life science exploration and experimentation in biomedical research and development. The journal focuses on scientific and technical advances that enable and improve:
- Life sciences research and development
- Medication administration
- Biomedical and molecular imaging
- Personalized and precision medicine
SLAS (Society for Laboratory Automation and Screening) is an international professional society of academic, industry and government life sciences researchers, and developers and suppliers of laboratory automation technologies. The mission of SLAS is to bring together researchers from academia, industry, and government to advance life sciences discovery and technology through education, knowledge exchange, and community building. worldwide.
SLAS technology: Translating innovation into life sciences, 2022 Impact factor 2.7. Editor Edward Kai-Hua Chow, Ph.D., National University of Singapore (Singapore